Biography
Biography: Dr Awwad
Abstract
Type 1 diabetes mellitus is an autoimmune disease occurring in the pancreatic islets. type 1 diabetes usually have been considered as multifactorial disease in which environmental risk factors trigger an immune -mediated destruction of the pancreatic beta cells in genetically susceptible persons The aim of this study was to investigate the associations of type 1 diabetes mellitus with maternal, neonatal and environmental risk factors. Subject and methods: a case-control study was conducted on adolescent school students aged 12-18 years old. Cases were adolescent school students who were diagnosed with type 1 diabetes mellitus and the controls were non-diabetic students (age matched) were randomly selected from the same school. Results: The study found that, there was a significant association between type 1 diabetes mellitus and participant’s sex, history of childhood viral (mumps, measles and varicella) infections, short exclusive breast feeding, early neonatal illness, family history of type1 diabetes mellitus, pre-eclampsia, gestational diabetes, maternal age (p < 0.05). while there was no significant cant association between type 1 diabetes mellitus and birth order, route of delivery, family history of type 2 diabetes mellitus, family history of thyroid disease and maternal coffee or tea drinking during pregnancy(p> 0.05). Conclusion: From this study it can be concluded that certain maternal, neonatal and environmental risk factors were associated with the development of T1DM